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Article

An obligatory role of mind bomb-1 in notch signaling of mammalian development.

PloS one - 28 Nov 2007

Koo Bon-Kyoung, Yoon Mi-Jeong, Yoon Ki-Jun, Im Sun-Kyoung, Kim Yoon-Young, Kim Cheol-Hee, Suh Pann-Ghill, Jan Yuh Nung, Kong Young-Yun

Abstract excerpt

BACKGROUND: The Notch signaling pathway is an evolutionarily conserved intercellular signaling module essential for cell fate specification that requires endocytosis of Notch ligands. Structurally distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), cooperatively regulate the endocytosis of Notch ligands in Drosophila. However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1,...

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Identifiers

PMID: 18043734
DOI: 10.1371/journal.pone.0001221
PMCID: PMC2082076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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An obligatory role of mind bomb-1 in notch signaling of mammalian development.PMID 18043734Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

Mind bomb-2 is an E3 ligase for Notch ligand.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.Semantic proximity Read ↗

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.Semantic proximity Read ↗

Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.Semantic proximity Read ↗

The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly.Semantic proximity Read ↗

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.Semantic proximity Read ↗

Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.Semantic proximity Read ↗

Transcriptome analysis of the zebrafish mind bomb mutant.Semantic proximity Read ↗

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