Article

CD8⁺ T cells induce interstrand crosslinking-associated DNA damage in neurons

2026-03-17

Abstract excerpt

Viral pathogens cause neurologic sequelae during acute and post-acute phases of infection. CD8 + T cells are hypothesized to contribute to these effects, but the mechanisms through which they act are poorly understood. We posited that viral infections and/or antiviral immune responses induce DNA damage, which may underlie neuronal dysfunction. Using a model of neurotropic flavivirus infection, we found that genes...

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Identifiers and source

Literature Corpus work: 3b26cb1b-a732-5fcd-b964-0b4712f22bf4
DOI: 10.64898/2026.03.14.711737

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