Article

Modeling Alzheimer’s disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegeneration

2023-03-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Alzheimer’s disease (AD) is the most prevalent form of neurodegeneration. Despite the well-established link between tau aggregation and clinical progression, the major pathways driven by this protein to intrinsically damage neurons are incompletely understood. <bold>Methods:</bold> To model AD-relevant neurodegeneration driven by tau, we overexpressed wild-type...

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Literature Corpus work: 2c2d9ad3-d021-5bf6-87d3-6b51833ba6df
DOI: 10.21203/rs.3.rs-2617457/v1

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