Article

Production of functional oocytes requires maternally expressed <i>PIWI</i> genes and piRNAs in golden hamsters

2021-01-27

Abstract excerpt

Many animals have a conserved adaptive genome defense system known as the Piwi-interacting RNA (piRNA) pathway which is essential for germ cell development and function. Disruption of individual mouse Piwi genes results in male but not female sterility, leading to the assumption that PIWI genes play little or no role in mammalian oocytes. Here, we report generation of PIWI -defective golden hamsters, which reve...

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Literature Corpus work: a5751f76-8a1a-5bc5-844f-1879107a998e
DOI: 10.1101/2021.01.27.428354

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