Article

Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway

2025-02-16

Abstract excerpt

Telomere elongation is essential for the proliferation of cancer cells. Telomere length control is achieved by either the activation of the telomerase enzyme or the recombination-based Alternative Lengthening of Telomeres (ALT) pathway. ALT is active in about 10-15% of human cancers, but its molecular underpinnings remain poorly understood, preventing the discovery of potential novel therapeutic targets. Pooled CR...

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Literature Corpus work: a56d8812-2d51-5b0b-acd9-abcd4fb2fa94
DOI: 10.1101/2025.02.15.638448

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