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Article

Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry.

Cell reports methods - 25 Mar 2024

Tsubouchi Asako, An Yuri, Kawamura Yoko, Yanagihashi Yuichi, Nakayama Hirofumi, Murata Yuri, Teranishi Kazuki, Ishiguro Soh, Aburatani Hiroyuki, Yachie Nozomu, Ota Sadao

Abstract excerpt

Recent advancements in image-based pooled CRISPR screening have facilitated the mapping of diverse genotype-phenotype associations within mammalian cells. However, the rapid enrichment of cells based on morphological information continues to pose a challenge, constraining the capacity for large-scale gene perturbation screening across diverse high-content cellular phenotypes. In this study, we demonstrate the...

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Identifiers

PMID: 38531306
DOI: 10.1016/j.crmeth.2024.100737
PMCID: PMC10985231

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