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Article

Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Liu Hongliang, Lutz Michael, Luo Sheng

Abstract excerpt

BACKGROUND: Mild cognitive impairment (MCI) is a heterogeneous condition and MCI patients are at increased risk of progression to dementia due to Alzheimer's disease (AD). OBJECTIVE: In this study, we aim to evaluate the associations between polygenic risk scores (PRSs) and 1) time to AD progression from MCI, 2) changes in longitudinal cognitive impairment, and 3) biomarkers from cerebrospinal fluid and imaging....

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Identifiers

PMID: 34657885
DOI: 10.3233/JAD-210700
PMCID: PMC8957404

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