Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Darst Burcu F, Koscik Rebecca L, Racine Annie M, Oh Jennifer M, Krause Rachel A, Carlsson Cynthia M, Zetterberg Henrik, Blennow Kaj, Christian Bradley T, Bendlin Barbara B, Okonkwo Ozioma C, Hogan Kirk J, Hermann Bruce P, Sager Mark A, Asthana Sanjay, Johnson Sterling C, Engelman Corinne D

Abstract excerpt

Polygenic risk scores (PRSs) have been used to combine the effects of variants with small effects identified by genome-wide association studies. We explore the potential for using pathway-specific PRSs as predictors of early changes in Alzheimer's disease (AD)-related biomarkers and cognitive function. Participants were from the Wisconsin Registry for Alzheimer's Prevention, a longitudinal study of adults who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Aniline Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Longitudinal Studies

Share to Neuropsychological Tests

Share to Positron-Emission Tomography

Share to tau Proteins

Share to Thiazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 27662287
DOI: 10.3233/JAD-160195
PMCID: PMC5123972

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.PMID 27662287Read ↗

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read ↗

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers.Semantic proximity Read ↗

Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic IndividualsSemantic proximity Read ↗

Effect of Pathway-Specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-Related Biomarkers Among Asymptomatic IndividualsSemantic proximity Read ↗

From Polygenic Scores to Precision Medicine in Alzheimer's Disease: A Systematic Review.Semantic proximity Read ↗

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.Semantic proximity Read ↗

The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer's Disease.Semantic proximity Read ↗

A/T/N polygenic risk score for cognitive decline in old ageSemantic proximity Read ↗

Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementiaSemantic proximity Read ↗

Comparing Pathway-Informed Polygenic Risk Score Strategies: A multi-cohort evaluation of Amyloid-βSemantic proximity Read ↗

Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.Semantic proximity Read ↗

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer’s Disease risk predictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.