Article

Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenografts

2026-04-06

Abstract excerpt

<h4>SUMMARY</h4> Tumor ecosystems evolve in response to chemotherapy, but how treatment reshapes clonal architecture and the transcriptional programs of distinct cell states remains unclear. To investigate the response to chemotherapy by individual single cell-derived clones, we used a high-complexity lentiviral barcoding strategy by genetically labelling with unique, heritable and expressible barcode sequences i...

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Literature Corpus work: a4c25d48-8a90-5f23-89f4-c7224cb37bbf
DOI: 10.64898/2026.04.02.716097

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