Genetic and transcriptional evolution alters cancer cell line drug response.

doi:10.1038/s41586-018-0409-3

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Article

Genetic and transcriptional evolution alters cancer cell line drug response.

Nature - 1 Aug 2018

Ben-David Uri, Siranosian Benjamin, Ha Gavin, Tang Helen, Oren Yaara, Hinohara Kunihiko, Strathdee Craig A, Dempster Joshua, Lyons Nicholas J, Burns Robert, Nag Anwesha, Kugener Guillaume, Cimini Beth, Tsvetkov Peter, Maruvka Yosef E, O'Rourke Ryan, Garrity Anthony, Tubelli Andrew A, Bandopadhayay Pratiti, Tsherniak Aviad, Vazquez Francisca, Wong Bang, Birger Chet, Ghandi Mahmoud, Thorner Aaron R, Bittker Joshua A, Meyerson Matthew, Getz Gad, Beroukhim Rameen, Golub Todd R

Abstract excerpt

Human cancer cell lines are the workhorse of cancer research. Although cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied. Here we use genomic analyses of 106 human cell lines grown in two laboratories to show extensive clonal diversity. Further comprehensive genomic characterization of 27 strains of...

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PMID: 30089904
DOI: 10.1038/s41586-018-0409-3
PMCID: PMC6522222

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