Article

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

2021-01-08

Abstract excerpt

<title>Abstract</title> <p>Cellular heterogeneity is a major cause of treatment resistance in cancer. Despite recent advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate measured molecular profiles to the cellular activities underlying cancer. Here, we present an integrated experimental system that connects single cell gene expression to heterogeneous cancer cell growth, m...

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Literature Corpus work: f4472189-468d-5e9a-92f3-338d001fc6a7
DOI: 10.21203/rs.3.rs-132486/v1

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