Article

Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution

2023-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Cancer is a highly heterogeneous disease, where phenotypically distinct subpopulations coexist and could be primed to different fates. Both genetic and epigenetic factors may drive cancer evolution, however little is known about whether and how such a process is pre-encoded in cancer clones. Using single-cell multi-omic lineage tracing and phenotypic assays, we investigate the predictive feature...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83898df3-4094-5c42-8641-f764ddc1163c
DOI: 10.1101/2023.06.28.546923

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolutionDOI 10.1101/2023.06.28.546923Read

Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution.Semantic proximity Read

Mapping genomic and epigenomic evolution in cancer ecosystems.Semantic proximity Read

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics.Semantic proximity Read

Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursorsSemantic proximity Read

Inferring mutational timing and reconstructing tumour evolutionary histories.Semantic proximity Read

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomesSemantic proximity Read

A Pan-Cancer Single-Cell Compendium of Intratumoural HeterogeneitySemantic proximity Read

Learning the cellular origins of cancer using single-cell chromatin landscapesSemantic proximity Read

Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenograftsSemantic proximity Read

Comparative assessment of genes driving cancer and somatic evolution in noncancer tissues: an update of the NCG resourceSemantic proximity Read

The many faces of cancer evolutionSemantic proximity Read

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid NeoplasmsSemantic proximity Read