Article

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

2019-10-21

Abstract excerpt

Cultured cell lines are the workhorse of cancer research, but it is unclear to what extent they recapitulate the cellular heterogeneity observed among malignant cells in tumors, given the absence of a native tumor microenvironment. Here, we used multiplexed single cell RNA-seq to profile ~200 cancer cell lines. We uncovered expression programs that are recurrently heterogeneous within many cancer cell lines and ar...

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Literature Corpus work: ec235f31-4f39-51e9-a780-386365968f2b
DOI: 10.1101/807552

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