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Article

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools.

Genome medicine - 19 Feb 2024

Xiang Ruidong, Kelemen Martin, Xu Yu, Harris Laura W, Parkinson Helen, Inouye Michael, Lambert Samuel A

Abstract excerpt

Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic predisposition to disease, and many potentially clinically useful applications have been proposed. Here, we review the latest potential benefits of PGS in the clinic and challenges to implementation. PGS could augment risk stratification through combined use with traditional risk factors (demographics, disease-specific...

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Identifiers

PMID: 38373998
DOI: 10.1186/s13073-024-01304-9
PMCID: PMC10875792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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