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Fundamental differences in endoreplication in mammals and <i>Drosophila</i> revealed by analysis of endocycling and endomitotic cells

23 Apr 2013

Abstract excerpt

Throughout the plant and animal kingdoms specific cell types become polyploid, increasing their DNA content to attain a large cell size. In mammals, megakaryocytes (MKs) become polyploid before fragmenting into platelets. The mammalian trophoblast giant cells (TGCs) exploit their size to form a barrier between the maternal and embryonic tissues. The mechanism of polyploidization has been investigated extensively...

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PMID: 23613587
DOI: 10.1073/pnas.1304889110

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