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Article

Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.

Developmental cell - 6 Jun 2016

Bretscher Heidi S, Fox Donald T

Abstract excerpt

Conserved DNA-damage responses (DDRs) sense genome damage and prevent mitosis of broken chromosomes. How cells lacking DDRs cope with broken chromosomes during mitosis is poorly understood. DDRs are frequently inactivated in cells with extra genomes (polyploidy), suggesting that study of polyploidy can reveal how cells with impaired DDRs/genome damage continue dividing. Here, we show that continued division and...

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Share to Chromosome Segregation
Share to Chromosomes, Insect
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Micronuclei, Chromosome-Defective

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Share to Radiation, Ionizing

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Source

Open in PubMed Open full text

Identifiers

PMID: 27270041
DOI: 10.1016/j.devcel.2016.05.004
PMCID: PMC4901310

Genes

FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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