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Article

Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis.

Cancer letters - 28 Nov 2025

Herriage Hunter C, Hughes Cameron L, Fahey Sarah K, Calvi Brian R

Abstract excerpt

Polyploid Giant Cancer Cells (PGCCs) occur across multiple cancer types and are associated with therapy resistance, genome instability, disease progression, and metastasis. PGCCs can grow through endocycles, a variant cell cycle of alternating Growth (G) and DNA Synthesis (S) phases without cell division. Unlike programmed endocycles that occur during normal tissue development, PGCCs switch from mitotic cycles to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40886823
DOI: 10.1016/j.canlet.2025.218008
PMCID: PMC12510470

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