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Article

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells.

Experimental cell research - 1 Aug 2010

Salmina Kristine, Jankevics Eriks, Huna Anda, Perminov Dmitry, Radovica Ilze, Klymenko Tetyana, Ivanov Andrey, Jascenko Elina, Scherthan Harry, Cragg Mark, Erenpreisa Jekaterina

Abstract excerpt

We have previously documented that transient polyploidy is a potential cell survival strategy underlying the clonogenic re-growth of tumour cells after genotoxic treatment. In an attempt to better define this mechanism, we recently documented the key role of meiotic genes in regulating the DNA repair and return of the endopolyploid tumour cells (ETC) to diploidy through reduction divisions after irradiation....

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Identifiers

PMID: 20457152
DOI: 10.1016/j.yexcr.2010.04.030

Genes

NANOG
SOX2
PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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