Article

Interleukin-6 is critical in the development of <i>gcn2-</i> mutation associated pulmonary vascular disease in mice

2025-04-19

Abstract excerpt

Biallelic mutations in eukaryotic translation initiation factor 2 α kinase 4, EIF2AK4 (which encodes general control nonderepressible 2, GCN2) underpin heritable forms of pulmonary veno-occlusive disease (PVOD), a rare and fatal form of pulmonary hypertension. The mechanisms linking these are mostly uncharacterised. We demonstrate for the first time that homozygous loss of gcn2 is sufficient to cause mild pulmon...

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Literature Corpus work: a42b7f17-4bf8-5c81-9616-1162cb9b9b0d
DOI: 10.1101/2025.04.14.648729

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