Article

Ccn2 deficiency causes smooth muscle cell de-differentiation and severe atherosclerosis in hyperlipidemic mice

2023-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Cellular communication network factor 2 (CCN2/CTGF) is a matricellular protein with an established role in fibrotic diseases and cancers, and therapies targeting CCN2 is currently in Phase II and III clinical trials for idiopathic pulmonary fibrosis, pancreatic cancer and Duchenne Muscular Dystrophy. Recent studies have highlighed a protective role of CCN2 in aortic aneurysm disease, but its rol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d1eda3a-23e3-5676-ad32-0f10434f2368
DOI: 10.1101/2023.01.16.524161

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ccn2 deficiency causes smooth muscle cell de-differentiation and severe atherosclerosis in hyperlipidemic miceDOI 10.1101/2023.01.16.524161Read

Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.Semantic proximity Read

Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.Semantic proximity Read

Ccn2 deletion predisposes to aortic aneurysm formation and death in mice which is partially reduced by mineralocorticoid receptor antagonist treatmentSemantic proximity Read

Myeloid CCN3 protects against aortic valve calcificationSemantic proximity Read

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic DissectionSemantic proximity Read

Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed miceSemantic proximity Read

Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and AtherosclerosisSemantic proximity Read

Interleukin-6 is critical in the development of <i>gcn2-</i> mutation associated pulmonary vascular disease in miceSemantic proximity Read

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse modelSemantic proximity Read

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerabilitySemantic proximity Read

Single-cell RNA sequencing reveals aortic cellular heterogeneity in MSC_ITGB3-treated ApoE-/- mice on a high-fat dietSemantic proximity Read

A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular CalcificationSemantic proximity Read