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Differential IL‐1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

22 Aug 2017

Abstract excerpt

Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH). Circulating levels of interleukin‐1 (IL‐1) are raised in patients and animal models. Whether interplay between BMP and IL‐1 signaling can explain the local manifestation of PAH in the lung remains unclear. Cell culture, siRNA, and mRNA microarray analysis of RNA...

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PMID: 28828907
DOI: 10.1177/2045893217729096

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