Article

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

2024-06-05

Abstract excerpt

<title>Abstract</title> <p>Loeys-Dietz syndrome (LDS) is an aneurysm disorder caused by mutations that decrease transforming growth factor-β (TGF-β) signaling. Although aneurysms develop throughout the arterial tree, the aortic root is a site of heightened risk. To identify molecular determinants of this vulnerability, we investigated the heterogeneity of vascular smooth muscle cells (VSMCs) in the aorta of <ital...

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Literature Corpus work: 0a3ac1b9-a86d-5186-8615-78a1480d12a8
DOI: 10.21203/rs.3.rs-4420617/v1

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