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Article

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2014

El Kasmi Karim C, Pugliese Steven C, Riddle Suzette R, Poth Jens M, Anderson Aimee L, Frid Maria G, Li Min, Pullamsetti Soni S, Savai Rajkumar, Nagel Maria A, Fini Mehdi A, Graham Brian B, Tuder Rubin M, Friedman Jacob E, Eltzschig Holger K, Sokol Ronald J, Stenmark Kurt R

Abstract excerpt

Macrophage accumulation is not only a characteristic hallmark but is also a critical component of pulmonary artery remodeling associated with pulmonary hypertension (PH). However, the cellular and molecular mechanisms that drive vascular macrophage activation and their functional phenotype remain poorly defined. Using multiple levels of in vivo (bovine and rat models of hypoxia-induced PH, together with human...

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Identifiers

PMID: 24928992
DOI: 10.4049/jimmunol.1303048
PMCID: PMC4100597

Genes

STAT3
STAT6
STAT1

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