Article

The Unexpected Role of GCN2 Kinase Activation in Mediating Pulmonary Arterial Hypertension

2023-09-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart hypertrophy and failure. Published studies show that recessive mutations of EIF2AK4 gene (encoding GCN2, General control nonderepressibe 2 kinase) are linked to heritable pulmonary veno-occlusive disease (PVOD) in patients...

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Literature Corpus work: 2c8e3155-1c1f-567e-a8c8-5618186d0bca
DOI: 10.1101/2023.09.05.556450

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