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Immunoregulatory gene <i>GIMAP6</i> suppresses lethal atherosclerotic vasculopathy and ischemic heart failure

2026-01-28

Abstract excerpt

<h4>SUMMARY</h4> Controlling hyperlipidemia has reduced but not eliminated atherosclerotic cardiovascular disease as a predominant cause of human mortality. Here, we report that loss of the immunoregulatory gene GTPase of immunity-associated protein 6 ( GIMAP6 ), causes an inflammatory vasculopathy and accelerated atherosclerosis in the absence of hyperlipidemia. These pathologic changes in turn result in progre...

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Literature Corpus work
9fc6f4ad-7609-502e-9f6d-d6853dbe990e
DOI
10.64898/2026.01.26.701509
Open publication

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Immunoregulatory gene <i>GIMAP6</i> suppresses lethal atherosclerotic vasculopathy and ischemic heart failureDOI 10.64898/2026.01.26.701509
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