Article

Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model

2025-01-26

Abstract excerpt

Genetic defects in NOX2 can cause chronic granulomatous disease (CGD), characterized by increased susceptibility to infections and pronounced inflammatory responses that lead to granuloma formation. We developed a CGD model using Ncf2 -/- mice through controlled environmental exposure. Unlike in specific pathogen-free environment, these mice spontaneously developed pulmonary granulomas under clean-grade condition...

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Literature Corpus work: abb2cd37-aea2-5345-a90f-d8d918aa818e
DOI: 10.1101/2025.01.23.634507

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