Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice

7 Nov 2023

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic parenchymal lung disease characterized by repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix deposition for which unmet need persists for effective therapeutics. The bioactive eicosanoid, prostaglandin F2α, and its cognate receptor FPr (Ptgfr) are implicated as a TGF-β1-independent signaling hub for IPF. To assess this,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Obstructive Pulmonary Disease (COPD) Research
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Occupational and environmental lung diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37934604
DOI: 10.1172/jci.insight.172977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in micePMID 37934604Read ↗

Disruption of Prostaglandin F <sub>2α</sub> Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

A new perspective on idiopathic pulmonary fibrosis research: From multi-dimensional mechanistic exploration to advances in precision therapy.Semantic proximity Read ↗

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epitheliumSemantic proximity Read ↗

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

Immunological mechanisms and therapeutic approaches in pulmonary fibrosis.Semantic proximity Read ↗

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read ↗

Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosisSemantic proximity Read ↗

Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read ↗

Tracing the origin of pathologic pulmonary fibroblastsSemantic proximity Read ↗

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.