Article

Interrogating endothelial barrier regulation by temporally resolved kinase network generation

2022-09-20

Abstract excerpt

Vascular leak is a common disease complication, yet the signaling networks regulating barrier integrity are incompletely understood. We developed a novel methodology, Temporally REsolved KInase Network Generation (TREKING), which combines a 28-kinase inhibitor screen with machine learning and network reconstruction to build time-resolved, functional phosphosignaling networks. We demonstrated the utility of TREKING...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a41cc8f3-327c-5c5d-8ebc-82f9007ec431
DOI: 10.1101/2022.09.19.508598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interrogating endothelial barrier regulation by temporally resolved kinase network generationDOI 10.1101/2022.09.19.508598Read

A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial IntegritySemantic proximity Read

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis.Semantic proximity Read

Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock.Semantic proximity Read

In silico phenotype projection of endothelial ERK1/2 signaling.Semantic proximity Read

A high-sensitivity TIE2-GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations.Semantic proximity Read

Temporal Network Dynamics and Boolean Modeling Reveal Critical State Transitions and Regulatory Hubs in Preeclampsia PathogenesisSemantic proximity Read

Analysis of Mechanistic Pathway Models in Drug Discovery: p38 PathwaySemantic proximity Read

KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation DiseaseSemantic proximity Read

Loss of PTPRB function remodels VEGFR1 activation in tumors overexpressing the receptor tyrosine kinaseSemantic proximity Read

Biologically informed neural network models are robust to spurious interactions via self-pruningSemantic proximity Read

Cell state transition analysis reveals a causal network that controls critical limb ischemiaSemantic proximity Read

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic LockSemantic proximity Read