Article

Temporal Network Dynamics and Boolean Modeling Reveal Critical State Transitions and Regulatory Hubs in Preeclampsia Pathogenesis

2025-08-12

Abstract excerpt

<h4>Background: </h4> Preeclampsia (PE) is a severe hypertensive disorder of pregnancy driven by placental dysfunction. A complex interplay of inflammatory, metabolic, and endothelial pathways regulates the transition from a healthy pregnancy to a pathological state. However, the systems-level dynamics and the mechanisms that the predisposing factors determine diseases onset and progression remain to be uncovered....

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Literature Corpus work: c3e07a84-f3e5-5c58-8670-6286db838bb8
DOI: 10.1101/2025.08.08.25333339

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