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Article

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis.

American journal of physiology. Cell physiology - 1 May 2018

Babur Özgün, Ngo Anh T P, Rigg Rachel A, Pang Jiaqing, Rub Zhoe T, Buchanan Ariana E, Mitrugno Annachiara, David Larry L, McCarty Owen J T, Demir Emek, Aslan Joseph E

Abstract excerpt

Upon encountering physiological cues associated with damaged or inflamed endothelium, blood platelets set forth intracellular responses to ultimately support hemostatic plug formation and vascular repair. To gain insights into the molecular events underlying platelet function, we used a combination of interactome, pathway analysis, and other systems biology tools to analyze associations among proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29412690
DOI: 10.1152/ajpcell.00177.2017
PMCID: PMC6008067

Genes

RTN4

Provenance

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