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A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity

2025-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Disruption of the brain endothelial barrier is a hallmark of traumatic brain injury (TBI), and contributes to cerebral edema, coagulopathy, and delayed neurological deficits, yet there are no mechanism-guided therapies that directly stabilize human brain vessels. Here we used a three-dimensional (3D) human brain endothelial vessel platform with quantifiable macromolecular barrier function to ass...

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Literature Corpus work
b3c9aaa9-0933-5a10-ae71-4e311f6105cf
DOI
10.64898/2025.12.11.692686
Open publication

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A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial IntegrityDOI 10.64898/2025.12.11.692686
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