Article

Cell state transition analysis reveals a causal network that controls critical limb ischemia

2024-02-12

Abstract excerpt

Increased endothelial cell (EC) permeability significantly contributes to peripheral arterial disease and its severe manifestation, critical limb ischemia (CLI). CLI remains refractory to current pharmacological interventions, often requiring limb amputation and showing how limited our knowledge is about signaling pathways that control EC states. Here, we utilize a two-pronged approach, employing cell State Transi...

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Literature Corpus work: 497ab99e-068f-53ce-bf73-a36b524e420d
DOI: 10.1101/2024.02.09.579659

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