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Article

Analysis of Mechanistic Pathway Models in Drug Discovery: p38 Pathway

1 Feb 2008

Abstract excerpt

Mechanistic models of signal transduction have emerged as valuable tools for untangling complex signaling networks and gaining detailed insight into pathway dynamics. The natural extension of these tools is for the design of therapeutic strategies. We have generated a novel computational model of lipopolysaccharide-induced p38 signaling in the context of TNF-alpha production in inflammatory disease. Using...

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PMID: 17918858
DOI: 10.1021/bp070084g

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