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Article

KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease

1 Sept 2022

Abstract excerpt

Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical role in vascular morphogenesis and homeostasis. Its loss-of-function has been unequivocally associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease of genetic origin characterized by defective endothelial cell–cell adhesion and ensuing structural alterations and...

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PMID: 36047808
DOI: 10.1089/ars.2021.0263

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KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation DiseasePMID 36047808Read ↗

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Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coinSemantic proximity Read ↗

Rap1 and its effector KRIT1/CCM1 regulate β-catenin signalingSemantic proximity Read ↗

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