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Article

Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock.

PLoS computational biology - 1 Aug 2017

Botello-Smith Wesley M, Alsamarah Abdelaziz, Chatterjee Payal, Xie Chen, Lacroix Jerome J, Hao Jijun, Luo Yun

Abstract excerpt

Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-β superfamily members. The STKR1 activity is tightly controlled by their regulatory glycine-serine rich (GS) domain adjacent to the kinase domain. Despite decades of studies, it remains unknown how physiological or pathological GS domain modifications are coupled to STKR1 kinase activity. Here, by...

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Identifiers

PMID: 28827795
DOI: 10.1371/journal.pcbi.1005711
PMCID: PMC5578689

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