Article

Loss of PTPRB function remodels VEGFR1 activation in tumors overexpressing the receptor tyrosine kinase

2026-08-17

Abstract excerpt

The VEGF Receptor1 (VEGFR1) is a deceptive receptor tyrosine kinase (RTK). In early embryonic development, VEGFR1 negatively regulates angiogenesis by acting like a decoy receptor. Ligand binding transiently phosphorylates the receptor and induces a weak activation, even at high receptor density. Yet, in multiple cancers, overexpression of VEGFR1 plays a central role in tumor vascularization and growth. Unlike man...

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Literature Corpus work: d66a8cd5-9755-5b30-941b-4a8d50a55449
DOI: 10.64898/2026.08.17.745152

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