Article

Inflammaging-induced TRAF3 degradation impairs AMP biosynthesis to drive sarcopenia

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>Inflammaging is a recognized driver of age-related pathologies, yet its specific mechanistic link to sarcopenia remains poorly understood. Here, we identified a significant reduction of TNF receptor-associated factor 3 (TRAF3) in myoblasts exposed to aged serum and in skeletal muscles from both aging mice and humans. Genetic deletion of TRAF3 in myocytes or satellite cells induced early...

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Literature Corpus work: a4153a22-9cb7-5a38-8427-c190414ca621
DOI: 10.21203/rs.3.rs-8857997/v1

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