Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.

Nature cell biology - 1 Aug 2018

Madaro Luca, Passafaro Magda, Sala David, Etxaniz Usue, Lugarini Francesca, Proietti Daisy, Alfonsi Maria Vittoria, Nicoletti Chiara, Gatto Sole, De Bardi Marco, Rojas-García Ricardo, Giordani Lorenzo, Marinelli Sara, Pagliarini Vittoria, Sette Claudio, Sacco Alessandra, Puri Pier Lorenzo

Abstract excerpt

Fibro-adipogenic progenitors (FAPs) are typically activated in response to muscle injury, and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to promote muscle repair. We found that denervation causes progressive accumulation of FAPs, without concomitant infiltration of macrophages and MuSC-mediated regeneration. Denervation-activated FAPs exhibited persistent STAT3 activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipogenesis
Share to Denervation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy

Share to Muscular Atrophy, Spinal

Share to Myoblasts, Skeletal

Share to Sciatic Nerve

Share to Spinal Cord Injuries

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 30050118
DOI: 10.1038/s41556-018-0151-y
PMCID: PMC6145844

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.PMID 30050118Read ↗

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and diseaseSemantic proximity Read ↗

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitionsSemantic proximity Read ↗

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced FibrosisSemantic proximity Read ↗

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and DiseasesSemantic proximity Read ↗

Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesisSemantic proximity Read ↗

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers.Semantic proximity Read ↗

Skeletal muscle in health and diseaseSemantic proximity Read ↗

FAP-intrinsic Hedgehog signaling controls intramuscular adipogenesis, fibrosis, and myofiber regenerationSemantic proximity Read ↗

Mechanisms of cooperative cell-cell interactions in skeletal muscle regenerationSemantic proximity Read ↗

Type-2 innate signals are dispensable for skeletal muscle regeneration and pathology linked to Duchenne muscular dystrophySemantic proximity Read ↗

Adipose tissue is a source of fibro-adipogenic progenitors for regenerating skeletal musclesSemantic proximity Read ↗

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.