Article

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

2022-03-08

Abstract excerpt

<h4>Summary</h4> Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enhanced skeletal muscle lysosomal and mitochondrial function via targeted overexpression of Transcript...

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Literature Corpus work: 81ad5899-519e-5536-9427-0956bd945f37
DOI: 10.1101/2022.03.07.482891

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