Article

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

2022-01-15

Abstract excerpt

<h4>Objective</h4> Regulation of proteasomal activity is an essential component of cellular proteostasis and function. This is evident in patients with mutations in proteasome subunits and regulators, who suffer from proteasome-associated autoinflammatory syndromes (PRAAS). These patients display lipodystrophy and fevers, which may be partly related to adipocyte malfunction and abnormal thermogenesis in adipose t...

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Literature Corpus work: 7edf9299-052a-546c-9b14-7152c8288bca
DOI: 10.1101/2022.01.14.476367

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