Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

30 Jun 2025

Abstract excerpt

Aging is characterized by a decline in the functionality and number of stem cells across the organism. In this study, we uncovered a mechanism by which systemic inflammation drives muscle stem cell (MuSC) aging through epigenetic erosion. We demonstrate that age-related inflammation decreases monomethylation of H4K20 in MuSCs, disrupting their quiescence and inducing ferroptosis, a form of iron-dependent cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Extracellular vesicles in disease
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40588650
DOI: 10.1038/s43587-025-00902-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosisPMID 40588650Read ↗

Human skeletal muscle ageing atlasSemantic proximity Read ↗

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasisSemantic proximity Read ↗

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammationSemantic proximity Read ↗

Human skeletal muscle aging atlasSemantic proximity Read ↗

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic MusclesSemantic proximity Read ↗

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathwaySemantic proximity Read ↗

Transcriptional Diversity in Response to Aging Across Skeletal MusclesSemantic proximity Read ↗

Loss of stem cell regenerative capacity within aged nichesSemantic proximity Read ↗

Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle FunctionSemantic proximity Read ↗

Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscleSemantic proximity Read ↗

Single-cell atlas reveals age-related cellular shifts underlying fibrosis in murine synoviumSemantic proximity Read ↗

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.