Article

Fibroblast orchestration of inflammaging via NF-kB activation

2025-10-01

Abstract excerpt

<h4>Summary</h4> Aged tissue is characterized by chronic inflammation known as “inflammaging”. While this aging immune phenotype supposedly drives some of the most common diseases affecting the elderly, little is known about the structural drivers of inflammaging. In this study, we demonstrate that age-dependent activation of NF-kB in tissue fibroblasts remodels the immune architecture, promoting the emergence of...

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Literature Corpus work: 84721a31-bc16-5f43-ab79-4267b94aeb65
DOI: 10.1101/2025.10.01.679697

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