Article

GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Age-related susceptibility to sepsis and endotoxemia is poorly defined, although hyperactivation of the immune system and the expansion of the visceral adipose as an immunological reservoir are underlying features. Macrophages from older organisms exhibit substantial changes, including chronic NLRP3 inflammasome activation, genomic remodeling and a dysfunctional, amplified inflammatory response...

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Literature Corpus work: 7a3600fe-154a-5d43-b680-1ffe831f4fe7
DOI: 10.1101/2024.09.23.614375

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