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Article

Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy

25 Apr 2018

Abstract excerpt

Age-related muscle atrophy (sarcopenia) is the leading cause for disability in aged population, but the underlying molecular mechanisms are poorly understood. Here we identify a novel role for the secreted glycoprotein Dickkopf 3 (Dkk3) in sarcopenia. Forced expression of Dkk3 in muscles in young mice leads to muscle atrophy. Conversely, reducing its expression in old muscles restores both muscle size and...

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PMID: 29717119
DOI: 10.1038/s41467-018-04038-6

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