Article

TgA86 mouse model demonstrated potential markers for Bone Formation in Spondyloarthritis through ROS Detoxification, Folate Metabolism, and Inositol Phosphate Metabolism

2025-07-30

Abstract excerpt

<title>Abstract</title> <p>Background Spondyloarthritis (SpA) represents a collection of inflammatory conditions distinguished by abnormal bone formation within the axial skeleton, ultimately resulting in ankylosis. The precise mechanisms responsible for this pathological bone development remain poorly understood. The TgA86 mouse model, featuring overexpression of a mutant human TNF transgene, accurately recapitu...

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Literature Corpus work: 59cf4358-f3eb-5e14-acf1-7496243a9a9a
DOI: 10.21203/rs.3.rs-7116883/v1

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