Article

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

2020-02-20

Abstract excerpt

<h4>Background</h4> Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and proteome or differentiated Tau- versus age-dependent changes. <h4>Methods</h4> Paired, longitudinal RNA-sequencing and mass-spectrometry were performed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ddfed13d-5eca-5990-b36a-9f2ab2ef93de
DOI: 10.1101/2020.02.19.954578

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated analysis of the aging brain transcriptome and proteome in tauopathyDOI 10.1101/2020.02.19.954578Read

Integrated analysis of the aging brain transcriptome and proteome in tauopathy.Semantic proximity Read

Tau polarizes an aging transcriptional signature to excitatory neurons and gliaSemantic proximity Read

Systems genetic dissection of Alzheimer’s disease brain gene expression networksSemantic proximity Read

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in <i>Drosophila</i>Semantic proximity Read

Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse modelsSemantic proximity Read

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila modelsSemantic proximity Read

Tip60 protects against amyloid-β peptide-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegenerative progressionSemantic proximity Read

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a <i>Drosophila</i> knock-in tauopathy modelSemantic proximity Read

Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNSSemantic proximity Read

Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.Semantic proximity Read

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer’s Disease fly modelsSemantic proximity Read

Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.Semantic proximity Read