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Article

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.

Scientific reports - 13 Dec 2023

Ohtonen Sohvi, Giudice Luca, Jäntti Henna, Fazaludeen Mohammad Feroze, Shakirzyanova Anastasia, Gómez-Budia Mireia, Välimäki Nelli-Noora, Niskanen Jonna, Korvenlaita Nea, Fagerlund Ilkka, Koistinaho Jari, Amiry-Moghaddam Mahmood, Savchenko Ekaterina, Roybon Laurent, Lehtonen Šárka, Korhonen Paula, Malm Tarja

Abstract excerpt

LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cell-derived microglia-like cells (iMGLs) and how it corresponds to microglia in idiopathic PD brain is not known. Here we demonstrate that LRRK2-G2019S carrying iMGL recapitulate...

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Identifiers

PMID: 38092815
DOI: 10.1038/s41598-023-49294-9
PMCID: PMC10719377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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