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Article

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology - 1 Feb 2021

Gu Meidi, Zhou Xiaofei, Sohn Jee Hyung, Zhu Lele, Jie Zuliang, Yang Jin-Young, Zheng Xiaofeng, Xie Xiaoping, Yang Jie, Shi Yaoyao, Brightbill Hans D, Kim Jae Bum, Wang Jing, Cheng Xuhong, Sun Shao-Cong

Abstract excerpt

Metabolic reprograming toward aerobic glycolysis is a pivotal mechanism shaping immune responses. Here we show that deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis induction, rendering CD8+ effector T cells hypofunctional in the tumor microenvironment. Conversely, ectopic expression of NIK promotes CD8+ T cell metabolism and effector function, thereby profoundly enhancing antitumor immunity and...

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Share to Cytotoxicity, Immunologic
Share to Glucosephosphate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunotherapy, Adoptive

Share to Lymphocytes, Tumor-Infiltrating

Share to Melanoma, Experimental

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Identifiers

PMID: 33398181
DOI: 10.1038/s41590-020-00829-6
PMCID: PMC7855506

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