Article

Accurate Genomic Variant Detection in Single Cells with Primary Template-Directed Amplification

2020-11-20

Abstract excerpt

Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic diversity that require more accurate single-cell genotyping. Here we present primary template-directed amplification (PTA), a new isothermal WGA method that reproducibly captures >95% of the genomes of single cells in a more uniform and accurate manner than exis...

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Literature Corpus work: a33edc0e-df76-5d81-bd61-0f760883ea7e
DOI: 10.1101/2020.11.20.391961

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