Article

Somatic mutation landscapes at single-molecule resolution

2021-04-28

Abstract excerpt

<title>Abstract</title> <p>Somatic mutations drive cancer development and may contribute to ageing and other diseases. Yet, the difficulty of detecting mutations present only in single cells or small clones has limited our knowledge of somatic mutagenesis to a minority of tissues. To overcome these limitations, we introduce nanorate sequencing (NanoSeq), a new duplex sequencing protocol with error rates <5 errors...

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Literature Corpus work: 38921b05-d138-5798-b790-729d82198959
DOI: 10.21203/rs.3.pex-1298/v1

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